Is Anyone Positive for SSB antibodies without SSA?

[paisley62]

Is anyone here, who has been officially diagnosed with Primary Sjogren's, positive for both ANA and the SSB antibodies,  without also being positive for the SSA antibodies? 

Is my case unusual, or do lots of people have strongly-positive SSB antibodies without any SSA?

[SjoGirl]

Yes and readings have changed over time. SSB was the only positive at first then ANA.

[MaryBee7]

Hi Paisley, I'm SSB  only and ANA positive. 

[Tharrell]

I'm goint show this post to my rheumy next week! He told me you can have ss a without ss b, but never a ss b without an a. He said it was a false positive! My neuro said I was weakly positive sjogren's and slightly hypotensive. Told me to increase liquids. I have always been on the low side of blood pressure with higher heart rate. My vitamin D levels just came back 23.5 and Thyroid was still normal. Can't get diagnosis or meds besides evoxac! Sigh!

[LadyDi]

Many with primary Sjogren's test negative for both SSA & SSB antibodies.

I tested negative for both SSA and SSB antibodies.
I have a positive ANA as well as a positive rheumatoid factor. My positive lip biopsy tested a focal score of greater than 2.

This seems to be why it takes so long and is so difficult for doctors to diagnose Sjogren's Syndrome. I had to meet 3 criteria out of a list of approx. 6 to 7 criteria before my docs would consider me as a positive diagnosis of Sjogren's.

[CAT1962]

Paisley,  how weird that I JUST posted about this! Please see my post!  So frustrated right now!

[aussie mum]

My daughter's results are the other way round Positive SSA but negative SSB.
She also has high ANA 1:1280 Speckled, High RF, ESR & CRP.

[SueAnn]

I am SSB and ANA positive and SSA negative. 



SueAnn

[MaryBee7]

Can it be that once again blood work is elusive?  I tested positive/dx with RA in 2007 now no trace.  At same time tested over and over for Sjogren's and nothing. 

[BonusMom]

Hi Paisley, I'm SSB  only and ANA positive.

Ditto.

[Tharrell]

I am ss b only and everything else negative. However rheumy finally gave me sicca dx. I guess it's a start since I am finally getting treatment with plaquenil and evoxac. He still firmly denies a possibility of negative ss a and positive b. sigh..... Sad that symptoms have to get really bad and I was trying to avoid that!

[wellshii]

Had to post to an old thread,
I tested positive for ss-b but not ss-a,but my  genetics have no history of this disease. My genes are linked to type 1 diabtetes,which I show symptoms of,not Sjogrens. I read on another forum where there was a guy who had the same scenario,and ended up being diagnosed type 1 diabetic . There is still alot of science to investigate behind these autoimmune diseases,but so far looks like type 1 diabetics might show ss-b antibodies as well. I had my tests yesterday for type 1 including the gad-65 antibody test and glucose tolerance test . I'll update as soon as the results come in of anyones interested.

[Nugget]

In 2013 I was postive ANA.  When I finally got an appointment with a rheumy in April of 2014, my blood tests came back also postive SSB.  So in a year I picked up another antibody, I guess.  Everything else came back negative.

[SjoGirl]

Yep

[tlavery]

Yes.  Positive ANA 1:160 speckled and posiyive SSB 8.0 (normal under 0.9).  Rheumy is treating with plaquenil and salagen, but will only diagnose as sicca syndrome.  Pain clinic gave me gabapentin too thankfully.