Author Topic: Heart medicine to kill off EBV  (Read 2319 times)

Maria3667

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Heart medicine to kill off EBV
« on: March 15, 2016, 04:06:45 PM »
Is there hope for us now researchers have found a commonly prescribed heart medicine is able to kill off Epstein Bar Virus, which is often associated with Sjogren's?

Only snag is ... this medicine causes dry mouth  :o !

See: http://m.pnas.org/content/early/2016/03/09/1523686113.abstract
52. DES-daughter ('67), Lyme's ('98), GAD ('98), Sjogren's ('02), hypothyroid ('04), endometriosis ('14), osteoarthritis ('16), blepharitis ('18), frozen shoulder ('19). Pilocarpine, thyroid meds, 25mg quetiapine, 5% testosterone. Allergies: sodium hydroxide, nickle, methylisothiazolinone, latex

Sharon

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Re: Heart medicine to kill off EBV
« Reply #1 on: March 16, 2016, 03:28:41 AM »
OMG amazing news Maria!
I've been waiting for this as EBV has always been somewhere in the background of all my symptoms.
Not clear from the abstract if the medicine is effective at all stages of EBV.
Do you have access to the full article?
Sjogren's (+ RA): positive ANA, RNP, RNP-A, APCA. Severe eye dryness + inflammation, multiple sensitivities and allergic reactions, fatigue. 
ORENCIA, Restasis, Anti-inflammatory diet, Vit. D & C, Ubiquinol 100mg, Omega 3....

Sharon

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Re: Heart medicine to kill off EBV
« Reply #2 on: March 16, 2016, 03:58:23 AM »
I see the med is a diuretic...problematic for me.
Question is how long would the course of treatment be?
Sjogren's (+ RA): positive ANA, RNP, RNP-A, APCA. Severe eye dryness + inflammation, multiple sensitivities and allergic reactions, fatigue. 
ORENCIA, Restasis, Anti-inflammatory diet, Vit. D & C, Ubiquinol 100mg, Omega 3....

Maria3667

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Re: Heart medicine to kill off EBV
« Reply #3 on: March 16, 2016, 10:02:20 AM »
Hi Sharon,

Yes I suspect EBV and/or CMV is still the main suspect in our systems. In 2014 scientists found that CMV infection could lead to the development of Sjogren's.

Unfortunately I can't get hold of the full text, but this is a bit more elaborate (hope I'm allowed to copy paste this!):

There are eight types of herpes viruses, and according to the World Health Organization the majority of the world?s population is infected with at least one. Despite the virus? many different forms, there?s only one family of drugs capable of treating these infections. Worse is that these viruses are becoming resistant to our efforts to control it. However, a research team from the University of Utah may have identified an alternative drug class to treat this common infection, according to a recent study.

While genital and oral sores may be the best-known symptoms from herpes virus, different members of the herpes family virus can cause more serious ailments such as mononucleosis and shingles. Viral infections cannot be cured or treated, but antiviral medications work to stop the virus from replicating, Livestrong reported. According to the Centers for Disease Control and Prevention, this viral suppression prevents the viruses from overriding a patient's body, and can lessen symptoms and reduce the length of time a person is sick.

For years, a team of researchers from the University of Utah have investigated different ways of treating a herpes virus infection. The focus of their research has been targeting a specific protein found on all herpes viruses, known as SM. The research team specifically focused on the Epstein Barr virus (EBV), a herpes virus that causes mono and is associated with several human cancers. The team used an online chemical library to scan different chemicals that may be able to target the SM protein. Lead researcher, Dr. Sankar Swaminathan, Chief of Division of Infectious Diseases at the University of Utah told Medical Daily that spironolactone, a drug commonly used to treat heart failure for over 50 years, was tagged as possibly having these properties.

?As soon as we saw that it [spironolactone] was a drug that was already known to be usable in humans, we went ahead and examined its abilities,? Swaminathan told Medical Daily.

Like drugs commonly used to treat EBV infections, spironolactone targets the herpes virus? ability to replicate. However, spironolactone goes about doing so differently. Current drugs work to block a middle step in the viral infection cycle by inhibiting virus? ability to replicate DNA. Spironolactone, however, works by targeting a step that comes later in the infection cycle. Although both accomplish the same goal, this difference is important because it indicates that new treatments may be effective on viral strains that have become resistant to currently available treatment options.

?We think there is a real need for drugs with different mechanisms from the ones we have now,? said Swaminathan. ?All the drugs that are clinically available work on the same step of herpes virus replications.?

Because the SM protein exists on all forms of the herpes virus, potential uses for spironolactone may not be limited to just treating EBV. At the moment, spironolactone is not yet ready for use as a herpes virus antiviral. According to Swaminathan, in its current form, spironolactone is far too toxic to use for treating the herpes virus and its side effects range from compromising kidney function to increasing secretion of salt. However, the team is confident that they will be able to separate spironolactone?s heart failure properties from its antiviral properties, making it not only effective but also safe for use. 

?We think there is great potential to modify this molecule so that it can work as an antiviral without having undesired side effects," explained Swaminathan in a recent statement. "We think it can be developed it into a new class of antiviral drugs to help overcome the problem of drug resistant infections."

Source: Verma D, Thompson J, Swaninathan S. Spironolactone blocks Epstein?Barr virus production by

inhibiting EBV SM protein function. Proceedings of the National Academy of Sciences. 2016


http://www.medicaldaily.com/herpes-virus-epstein-barr-virus-mononucleosis-377867
52. DES-daughter ('67), Lyme's ('98), GAD ('98), Sjogren's ('02), hypothyroid ('04), endometriosis ('14), osteoarthritis ('16), blepharitis ('18), frozen shoulder ('19). Pilocarpine, thyroid meds, 25mg quetiapine, 5% testosterone. Allergies: sodium hydroxide, nickle, methylisothiazolinone, latex

Sharon

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Re: Heart medicine to kill off EBV
« Reply #4 on: March 16, 2016, 10:28:44 AM »
Strange how all my doctors never suggested any treatment for my chronic EBV
claiming nothing treats it...
According to the article you pasted there currently exist options of some sort.
Sjogren's (+ RA): positive ANA, RNP, RNP-A, APCA. Severe eye dryness + inflammation, multiple sensitivities and allergic reactions, fatigue. 
ORENCIA, Restasis, Anti-inflammatory diet, Vit. D & C, Ubiquinol 100mg, Omega 3....

Maria3667

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Re: Heart medicine to kill off EBV
« Reply #5 on: March 16, 2016, 03:00:38 PM »
Yes, that surprises me too! Maybe they mean antibiotics in the early phases? .... Clueless here !
52. DES-daughter ('67), Lyme's ('98), GAD ('98), Sjogren's ('02), hypothyroid ('04), endometriosis ('14), osteoarthritis ('16), blepharitis ('18), frozen shoulder ('19). Pilocarpine, thyroid meds, 25mg quetiapine, 5% testosterone. Allergies: sodium hydroxide, nickle, methylisothiazolinone, latex

LadyDi

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Re: Heart medicine to kill off EBV
« Reply #6 on: March 16, 2016, 06:20:58 PM »
Hi, I thought that I would join in the discussion about the medication spironolactone. It is a heart medication, however, it is used off label for other medical conditions.

Spironolactone was prescribed to me a few years back for off label use. My dermatologist prescribed it to me for cystic acne and for very bad oily skin on my face. It has done a fabulous job of keeping my skin in check. I have no knowledge of it being used to treat either of those viruses or Sjogrens.

I don't want to be the bearer of bad news, but I have been on this med for two years and my Sjogrens is still going strong. I know nothing of EBV or CMV because I have never been tested or confirmed to have either. I am sero positive for Sjogrens with a positive lip biopsy.
Primary Sjogrens, fibromyalgia,partial thyroidectomy/hypothyroid, asthma, chronic sinusitis/nasal polyps, environmental allergies. Plaquenil, Evoxac,Restasis,Neutrasal, levothyroxine, Zyrtec, Singulair, Proair inhaler, spironolactone

Sharon

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Re: Heart medicine to kill off EBV
« Reply #7 on: March 17, 2016, 04:25:04 AM »
Thanks for the input Ladydi,
Didn't expect it to actually cure SJS, but since I do have chronic EBV I dont know what symptoms are from what illness
anymore and viruses can always make any situation worse since the AI system is kept hyperactive when
it's constantly trying to keep viruses at bay.
Sjogren's (+ RA): positive ANA, RNP, RNP-A, APCA. Severe eye dryness + inflammation, multiple sensitivities and allergic reactions, fatigue. 
ORENCIA, Restasis, Anti-inflammatory diet, Vit. D & C, Ubiquinol 100mg, Omega 3....

Nomad

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Re: Heart medicine to kill off EBV
« Reply #8 on: March 17, 2016, 07:54:47 AM »
I have lupus which I've had for many years.  Then in my fifties I noticed dry mouth and eyes.  I went to the doc and was determined to have Sjogrens.

One of my other docs tested me for EBV and it was determined that I was exposed...an old exposure. I don't think I was ever tested before.

Many questions:
Is there indication that EBV can cause lupus too?
Is it common that when one has lupus, that later in life they are also dx'd with Sjogrens?
My EBV was not active.  What symptoms indicate activity?

Thank you.
SLE, Sj.  Syndrome, IC, Atypical Trigeminal Neuralgia, ITP (low platelets)... Various meds and lots of vitamins. Trying to eat healthy; seems to help a little.