Author Topic: IGA 4  (Read 2433 times)

911lynn

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IGA 4
« on: May 28, 2014, 04:59:23 PM »

Last month I was diagnosed with a rare variant of SS. It has no name, just the letters IGA and the number 4. I can not find any info about this disease.  :'( Can anybody help me out?


Joe S.

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Re: IGA 4
« Reply #1 on: May 28, 2014, 06:30:11 PM »
IgA search may provide you some answers.
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Velcro

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Re: IGA 4
« Reply #2 on: May 29, 2014, 08:57:24 AM »
I think Joe is right.  It falls under IGA, and looks like IGA 4 is a classification of a certain antibody in the IGA series.

anita

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Re: IGA 4
« Reply #3 on: May 29, 2014, 09:04:58 AM »
It's IgG 4, not IgA

If you search IgG 4 and Sjogren's you'll find related diseases associated with IgG 4.
52 yr old SjS, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) IgG def., Cushing's, Asthma, Gastroparesis.  Sero-neg w/+ lip biopsy.  Meds: IVIG & pre-meds, Arixtra, Aspirin, Plaquenil, Cardizem, Toprol XL, Domperidone, Nexium, Midodrine, Symbicort, Fentanyl, Percocet, Zofran

Velcro

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Re: IGA 4
« Reply #4 on: May 29, 2014, 09:25:58 AM »
The (4) could also be your range.  In many labs, anything under 7 when testing IGA is considered IGA deficient.  I would call your Doctor that ran the test and ask him what the 4 is.

anita

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Re: IGA 4
« Reply #5 on: May 29, 2014, 10:06:58 AM »
The IgG 4 is a subclass of the immune system (IgG--4th subclass).

Here's some links to show some of the different diseases related to IgG 4

http://www.uptodate.com/contents/overview-of-igg4-related-disease

http://www.ncbi.nlm.nih.gov/pubmed/21628856

http://www.ncbi.nlm.nih.gov/pubmed/20457280
52 yr old SjS, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) IgG def., Cushing's, Asthma, Gastroparesis.  Sero-neg w/+ lip biopsy.  Meds: IVIG & pre-meds, Arixtra, Aspirin, Plaquenil, Cardizem, Toprol XL, Domperidone, Nexium, Midodrine, Symbicort, Fentanyl, Percocet, Zofran

Carolina

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Re: IGA 4
« Reply #6 on: May 29, 2014, 12:58:47 PM »
Hi Lynn,

I have Primary Immune Deficiency.  I am deficient in IgG and IgM.

These are my numbers:

G Subclass total  402 range  767-1590
G Subclass 1  198  range 341-894
Subclass 2  124  range 171-632
Subclass 3  18.1  range 18.4-106
Subclass 4 – 5.6 range 2.4-121

My IgG Subclass 4 is actually the only subclass that is in the normal range.

There are subclasses for IgG as far as I know the others do NOT have subclasses.

These are my antibody numbers:

G   388         range  588-1573   
A 106                     range 46-287       
18            range 57-237
IGE  5                     range  4- 269     

Because my IgG is low, I have IVIG.

My IgM is also low but there is NO Treatment for that.


If your IgG 4 subclass is low, you may have some possible treatment with IVIG.

Hugs.  Elaine
Female-Elaine,79-CVID-pSJS-WMD (Eylea) C-PN-CAD-Osteoarth-SFN-Knee/Shoulder Degeneration-SIBO-Act.Purpura-Tinitus-Meniere's-Hiatal Hernia-Achalasia-Hand Surgeries, UTI's-Braces/Walker-IVIG Gamx-Medrol-Gabapentin-Atenolol-Pilocarpine-LDN-Nasonex-Lipitor-Estrogel-D-Mannose-NAC-Om. 3-Naltrexone-Esomep.

anita

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Re: IGA 4
« Reply #7 on: May 29, 2014, 01:16:25 PM »
Actually, the IgG 4 related diseases are from hyper IgG 4 levels, not deficiency. 

It's a new way doctors are looking at immune mediated diseases.
52 yr old SjS, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) IgG def., Cushing's, Asthma, Gastroparesis.  Sero-neg w/+ lip biopsy.  Meds: IVIG & pre-meds, Arixtra, Aspirin, Plaquenil, Cardizem, Toprol XL, Domperidone, Nexium, Midodrine, Symbicort, Fentanyl, Percocet, Zofran

911lynn

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Re: IGA 4
« Reply #8 on: June 02, 2014, 12:54:30 PM »
 :)
Thanks for all of your messages. I think I understand what IgG 4 means. If you don't mind I will use your information to compare with mine and get back to you.