Jason, I understand the reluctance you are feeling. We have all had the same concerns and it's stressful! I'm glad that you are weighing the options carefully. Knowledge is power, it pays to be informed and learn from the experience of others. The worst we generally see here is that people have stomach upset, a few have had an issue with nightmares. I believe that Plaquenil is safe as long as we are careful to watch for any adverse effects. I wish there were some better options and I know there will be in the future, but for now Plaquenil carries lowest risk in exchange for protection from disease progression and risk of complications. It also improves symptoms. It's a psychological shock when you're newly diagnosed. You're going through an adjustment and you sound like you need some time to give it more thought. Please keep reading and posting here. Know that you're not alone and you have a whole community here who will support you with any challenges you face. I'm glad you found us, welcome!