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Sjogrens Topics => Living With Sjogren's => Topic started by: markt on March 05, 2021, 09:05:37 AM

Title: OC-01 (Varenicline) Nasal Spray for the Treatment Dry Eye Disease
Post by: markt on March 05, 2021, 09:05:37 AM
It's been a while since I have checked in here, but wanted to relay some news and things to look forward for folks whose Sjogrens induced Occular Surface Disease is poorly controlled:

https://investors.oysterpointrx.com/news-releases/news-release-details/oyster-point-pharma-announces-fda-acceptance-filing-new-drug (https://investors.oysterpointrx.com/news-releases/news-release-details/oyster-point-pharma-announces-fda-acceptance-filing-new-drug)

https://eyewire.news/articles/oyster-point-pharma-submits-nda-to-fda-for-oc-01-nasal-spray-for-the-treatment-of-signs-and-symptoms-of-dry-eye-disease/ (https://eyewire.news/articles/oyster-point-pharma-submits-nda-to-fda-for-oc-01-nasal-spray-for-the-treatment-of-signs-and-symptoms-of-dry-eye-disease/)

About OC-01 Nasal Spray

OC-01 is a highly selective cholinergic agonist being developed as a multidose preservative-free nasal spray to treat the signs and symptoms of dry eye disease. The parasympathetic nervous system, the ?rest and digest? system of the body, controls tear film homeostasis partially via the trigeminal nerve, which is accessible within the nose. Administered as a preservative-free, aqueous nasal spray, in pre-clinical and clinical studies, OC-01 (varenicline) nasal spray was shown to have a novel mechanism of action with activation of the trigeminal parasympathetic pathway in the nasal cavity to stimulate natural tear film production. Human tear film is a complex mixture of more than 1,500 different proteins, including growth factors and antibodies, as well as numerous classes of lipids and mucins. This complex tear film is responsible for forming the primary refracting surface of the cornea, as well as protecting and moisturizing the cornea. OC-01 (varenicline) nasal spray is an investigational new drug and has not been approved for any indication in any country. The safety and efficacy of OC-01 (varenicline) nasal spray have not previously been established.
Title: Re: OC-01 (Varenicline) Nasal Spray for the Treatment Dry Eye Disease
Post by: Robi5 on March 10, 2021, 01:04:58 PM
This sounds very promising.  Thanks for posting this!  Is this occular condition rare for us, or is it quite common?   

Any advancement in our disease treatment is a welcome thought.