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Sjogrens Topics => Living With Sjogren's => Topic started by: Woolygimp on October 14, 2010, 03:03:51 PM

Title: Hydroxychloqoruine - loss of potency
Post by: Woolygimp on October 14, 2010, 03:03:51 PM
I take 400mg daily of the generic version of Plaquenil, hydroxychloroquine, and I've noticed the strangest occurrence over the 12+ months that I've been taking this medication.

First, I know how it's suppose to work... how it takes months of "build up" and that you aren't suppose to notice small and quick changes in dosages, but I say that's bullshit.  If I go a couple days without the medication, I can tell.

Now what seems to be happening is when I pick up a prescription, I notice the benefits of the medication for the first couple of weeks.  But as I get closer and closer to the end of the fill, I very gradually lose the benefits of the medication and feel sicker, more swollen, etc. and all this changes when I get my next fill.  It's almost as the medication is losing its potency relatively quickly.  It all becomes fine again when I get another fill and begin taking the next months, I almost immediately notice an improvement and I feel much, much better.

I store the hydroxychloroquine at room temperature and don't leave it in the heat or anything, so I don't know what could be causing this.   I'm trying to get the brand name, because it may be a problem with the generic for all I know, but I doubt that Walgreens will fill it with the brand name (they don't make as much money filling brand name prescriptions). 

Anyway, I thought this was very odd and I've noticed it over, and over... this isn't a one time occurence, and was just curious if anyone had any ideas.
Title: Re: Hydroxychloqoruine - loss of potency
Post by: DragonflyC on October 14, 2010, 04:54:40 PM
I take the generic, but I haven't noticed any lessening of its impact except when I'm flaring.
Title: Re: Hydroxychloqoruine - loss of potency
Post by: anita on October 14, 2010, 05:52:21 PM
Being that you're describing reoccurring monthly changes, I wonder if it's a hormonal thing, not the plaquenil. 

I have taken plaquenil for a couple years and never had anything like you describe (and I take the generic).  I'll be interested in reading other comments.

Take care
Title: Re: Hydroxychloqoruine - loss of potency
Post by: Kerrikins on October 14, 2010, 06:03:24 PM
My flares are connected to my hormones and I notice I seem to feel bad at a certain time every month. I think the potency of the med wouldn't be affected if you store it normally. I take that same med and I think my pharmacy gets them in a huge batch so for several months in a row I am probably taking pills that were all made at the same time.
Title: Re: Hydroxychloqoruine - loss of potency
Post by: warmwaters on October 14, 2010, 06:09:30 PM
Just a moment's humor ;D - The title of this thread sounds like something one of gentleman of the group might have posted.   :o

But no, I haven't had a cyclical loss of the effectiveness. The other thing is that I imagine the medicine itself is going to be of different ages when you purchase it - some might have been manufactured recently, and some several months ago.

Title: Re: Hydroxychloqoruine - loss of potency
Post by: season on October 14, 2010, 07:44:29 PM
I take the generic and I haven't noticed anything like this.
Title: Re: Hydroxychloqoruine - loss of potency
Post by: Bopeep on October 15, 2010, 02:46:04 AM
Just a moment's humor ;D - The title of this thread sounds like something one of gentleman of the group might have posted.   :o

But no, I haven't had a cyclical loss of the effectiveness. The other thing is that I imagine the medicine itself is going to be of different ages when you purchase it - some might have been manufactured recently, and some several months ago.


hehe I had the exact same thought lol
Title: Re: Hydroxychloqoruine - loss of potency
Post by: Epson on October 15, 2010, 11:20:28 AM
No one knows exactly how long pill form drugs are good for, but it's a long time if stored correctly.  The government has a stockpile of 68,269 pounds of opium and morphine stored at Fort Knox and West Point, an amount that could satisfy the nation's legal needs for about a year. Most of these drugs date back to the cold war era and I have also read that some dates back to WWII.  They did process some of the aging opium into morphine, but I'm not sure why.