Table of antibodies

[Linda196]

I'm sorry this image is so small, but you should be able to click on the image and enlarge it. If that doesn't work, right click, select open in a new tab or window, and it will show full sized.

[adinack74]

What source is this chart from?

[Linda196]

This chart is an adaptation from one of my text books, The Principles and Practice of Medicine, 23rd ed. Originally published by Appleton & Lange, 1996

[adinack74]

Thank you!  My anti-SCL-70 antibody test is positive but all other antibody tests are negative.  This is the first thing I've seen that relates the anti-SCL-70 to Sjogrens.

[new2sjs2012]

I hope to get my test results next week.
Thanks

[Linda116]

Can you post an explanation for each of the autoantibodies?   I know what the ANA, Anti SSA, SSB and RF are, but do not know what the others are.   

Thanks.

[Arielluria]

I'm pretty new to SS and new to this site. I would also like an explanation since I am positive for SSA & SSB and my RA Factor is high (184....range is 0-13.9), my C3 is low (81 .... range from 90-180) and C4 is normal (18....range 9-36). My rheumatologist didn't suspect RA.

[mscamillec]

Linda,

thanks for the chart! i just seen my rheumy(his partner) because i had a  High ANA 1:40 speckled and a positive sjogrens  AB (SSB). i originally went to the practice 2 years ago with a high Ana and the other doc was abrupt (i was told to go) i never had the Sjogrens AB test done previously through independent labs sand same results 2 years later. when the rheumy saw my newest labs he said be prepaired to go on medication,and he drew other labs (cpk,adolace,g6pd, &compliment CH50). I have been diagnosed with ms almost for 10 years and the ms injections have no effect on mr ever but doing them like i should. ms and Sjogrens have the same issues even brain lesions during a flare. Makes me think   i asked the rheumy if i could of had sjogrens all along instead of ms and he said there is a possibility. i dont know if you can have both.

thank you,
camille

[susanep]

Thank you for posting this chart. I think it is very helpful.

susanep

[cccourt1942]

Linda:  I am asking a question to which I should know the answer.  You can see/tell I am a newbie.  I saw my rheumatologist yesterday for the second time.  I was seen/tested first of Dec.  He called a week later to confirm positive for SS (primary).  I've lived on this board pretty much since then.

He told me yesterday I tested positive for "all three" antibodies for SS.  I thought there were more..then decided he meant for primary type.  My question is this:  are the antibodies  he is referring to ANA and SS-A and SS-B?  I know you are wondering, well..why didn't she ask the doctor.  Well..there was SO much information he was giving me...and he had been so surprised...believing I has Sicca Complex...that I just never got back to it.  Carolina suggested that I get a copy of my report-and I shall.  There is just SO much.  Can you help me?

[Carolina]

Good to see this chart. Since I don't have any autoantibodies, I've never paid much attention, I have to say.

But something like this is so helpful!

Hugs,  Elaine
'

[Linda196]

@ccourt, my first instinct would be to include the anti-RNP with the anti-SSa and SSb. The ANA is very non-specific, and usually just leads the doctor to determine that there is an immune condition.

The anti-RNP is more commonly associated with Lupus, but often shows up in Sjogren's, without being paired with the anti-SM that indicates Lupus. It seems to be an indicator of Raynaud's when present in Lupus patients, just as a point of interest.

He may also have meant the Rheumatoid Factor (RF) which, despite its name, is not a specific indicator of Rheumatoid Arthritis. RF shows up in a number of autoimmune diseases when there is joint involvement.

I completely understand the information overload situation, and it sounds like your doctor was experiencing a bit of the same, seeing results he wasn't prepared for!

[cccourt1942]

Thx...that was a great answer.  You specified re: the  arthritic markers...and that is what I was (in my pea brain) denying.  So it confused me.  Thx so much.

[AndyFel]

Thx...that was a great answer.  You specified re: the  arthritic markers...and that is what I was (in my pea brain) denying.  So it confused me.  Thx so much.

I can't seem to make the chart bigger.

[Linda196]

Thnanks for bringing that to my attention, AndyFel. not sure why clicking on it isn't working, but if you aren't on a phone, you can right click on it, open in a new tab or window, and it will be greatly enlarged.