Author Topic: Help with blood test interpretation  (Read 534 times)

Scientist8

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Help with blood test interpretation
« on: November 04, 2019, 07:40:21 AM »
Hi - I'm a 52 year old male.
Dentist and doctors suspected Sjogrens (details below). Blood test showed:

SS-A and SS-B negative

ANA positive 1:320, homogeneous pattern
RNP positive (but weak, 2 where normal is <1)

Negative for ds DNA (3 where <4 is neg), Negative for SM, SM/RNP and Chromatin
edit: normal/negative RF

Are the results affected by the fact that things have been better for the last month or two?
RNP does not give homogeneous pattern as far as I know (?)

My history:
Mononucleosis (~30 yrs ago)
Developed GI problems immediately after
Frequently raised liver enzymes (ALT/AST)
Low white blood cells (specifically neutrophils)
Pericardial friction rub? (doctor heard it for a long time, but echo showed diastolic heart problems without obvious pericarditis)
GI problems became severe ~ 20 years ago (microscopic colitis) with severe fatigue, joint pain, fever, weight loss, etc

No obvious Raynaud's and the joint pain in my hands is only minor (more trouble with knees, ankles, lower back).
Dry mouth and dry eyes for many years, too many cavities,
Oral surgeon probed parotid glands and noted dryness and possible inflammation, panoramic x-rays showed odd speckles in parotid glands (seen is Sjogren's sometimes)

Anyone with similar experience?

Thanks,

S



« Last Edit: November 04, 2019, 04:35:59 PM by Scientist8 »

eye2dry

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Re: Help with blood test interpretation
« Reply #1 on: November 04, 2019, 07:53:51 AM »
Hi there.

What was your RF and sed rate?

Shelly
medications: synthroid- Cymbalta- plaquenil- lots of supplements

***Lord help me to be the person my dog thinks I am***

Scientist8

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Re: Help with blood test interpretation
« Reply #2 on: November 04, 2019, 08:03:15 AM »
Negative RF. Sedimentation rate was normal 10 years ago.

markt

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Re: Help with blood test interpretation
« Reply #3 on: November 04, 2019, 11:29:54 AM »
There are other antibodies at play in Sjogrens beyond SS-A/B.

If I were you, I'd request the "Sjo Test" by Bausch and Lomb... 

Without getting into the weeds, it looks into other highly sensitive markers that have been used to evaluate, determine, and capture an active auto immune response.  e.g. antibodies to SP-1, PSP, CA-IV, CAVI, Immunoglobulin counts Ig1-4, IgG, and Blood Compliment C3/C4.

Beyond that, I'd have your ophthalmologist do a RPS Inflamma dry test (or series of them) for a specific protein called MMP-9. 

Many people are missed because the markers above are not tested from the start.

V/r,

Mark
« Last Edit: November 04, 2019, 11:31:34 AM by markt »

Scientist8

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Re: Help with blood test interpretation
« Reply #4 on: November 04, 2019, 04:32:21 PM »
Sounds like good advice. Thanks.

Kathy57

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Re: Help with blood test interpretation
« Reply #5 on: November 05, 2019, 09:37:11 AM »
scientist8,

Welcome to the group.  I do not know much about lab results but I believe that many of us have seronegative Sjogrens.  Are you planning on getting a lip biopsy?  I have been told that it is more accurate than blood work, but be careful on who performs it and on who reads it.

Is anyone treating you yet?  That is  important.  I hope you find good answers and good treatment🤗

Kathy
Diagnosed Sjogrens Aug. 1st 2014.  Plaqinil, Evoxac, Prevacid, Lexapro, Hypothyroid, Esophagel Reflux, Gastritis, Barretts Esophagus, failed sinus surgery with 3 nasal septal perforations.  (Can't see it from the outside)  Asthma, albuterol, Dulera, Nebulizer, Osteoporosis.

rcristal

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Re: Help with blood test interpretation
« Reply #6 on: November 05, 2019, 01:34:30 PM »
  I am new to the board but have been dealing with  Sjogrens for a very long time.  I am a 69 year old man and am becoming more and more concerned about all of the blood tests.  I am certain I don't need to tell any of you how tiring all of this is.  Recent blood tests continue to show
Very low Compliment 3 and slightly low CBC.  However, now I am showing elevated Liver enzymes.  Input from fellow sufferers would be most appreciated.

Best to all.

Rcristal

irish

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Re: Help with blood test interpretation
« Reply #7 on: November 05, 2019, 07:36:29 PM »
I haven't kept up with all the new blood work as I was diagnosed with sjogrens in 2003 with a positive lip biopsy....this was a total surprise to me and my doctors. Just a sort of accidental lip biopsy done by a new rheumatologist who had talked to me on the phone. She asked if my glands were sore in my jaw and I said sort of. The put me on 2 antibiotics to start after a lips biopsy. Lucky guess I called it.

Anyway, a couple of years later I took part in a sogrens study at our state university and my sjogrens blood work SSa and La ere positive along with the ANA. I had had symptoms since age of 21 or so and was 60 at age of diagnosis. I am 76 now soon to be 77 and the symptoms seem to keep adding up. I can't give you much advice cause I can't take the immunosuppressants but have been on IV IG since 2006 for my Myasthenia gravis. I have a total of 5 autoimmune diseases.

Just to let you know, when the liver enzymes go up it is time to see a Gastroenterologist. The Sjogrens can affect the liver and pancreas plus the gastrointestinal track. Any place in the body that secretes mucus or other body secretions. I also see a lung specialist to keep track of my lungs cause they can be affected also.

I have to admit I am wearing out from all the doctors appointments cause the fatigue is getting worse. It is the disease that keeps on giving. Welcome to all the new people. This is a great place to hang out and learn things. Irish

Tharrell

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Re: Help with blood test interpretation
« Reply #8 on: November 06, 2019, 08:51:21 AM »
Positive ANA plus positive RNP is specific for a diagnosis for mixed connective tissue disease, which I have. Sjogren’s can be part of that, as mctd is an overlap disease of lupus, scleroderma, raynauds. I have both mctd as well as sjogren’s.
MCTD, sjogren's,dRTA,CVID, sero neg. ra,achalasia,Morvan’s syndrome,familial dysautonomia,POTS, MCI, IC. Occular neuromyotonia migraines,raynauds,B6,Florinef, propanolol,sodium bicarb, plaquenil,requip,B2,topiramate, synthroid,diazepam,trulance,enbrel,cevimeline,
arava,omeprazole, mexiletin

rcristal

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Re: Help with blood test interpretation
« Reply #9 on: November 07, 2019, 07:44:58 AM »
  Thanks for the input.  I, too am totally worn out with Doc visits.  In the past two+ weeks I have had four visits, a CT Scan, an ultra sound and 7 needles stuck in me lol.  Tomorrow is an important visit to the GI Doc to check out Liver enzymes again.  On top of it all, they are a bit concerned about an old Pulmonary nodule.  I was an athletic and quite active Husband, Father, Businessman and Coach.  Now I am a worn out 69 year old lol.

Enough complaining for a while.  It is just really difficult.  I admire those of you who are worse of than me.  You have my respect.

Rcristal

susanep

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Re: Help with blood test interpretation
« Reply #10 on: November 07, 2019, 09:45:41 PM »
I was diagnosed with sjogrens without even having the lip biopsy. Then it was fibromyalgia by that same Rheumatologist.

Later I began with a new Rheumatologist and on first visit from the blood work he had done I was diagnosed with Lupus, and this year with Rheumatoid Arthritis. I just wait for the next one to be added as some know.

I go in the morning for my Rheumy appointment. I have a lot wrote down. I was suppose to go last week, but my hubby was sick.

I hope you find out what you may have. Always get a copy of your results too, and you have tests to compare.

susanep
Sjogren's, Lupus, Rheumatoid Arthritis, Hypothyroid, Fibro, Sleep Apnea, Diabetes 2, Asthma, and Gerd.  (Meds I take) Omeprazole, Pilocarpine, Levothyroxine, Effexor, Cpap, Aspirin, Mobic, Prilosec,, Xanax, Restasis, Systane,Vitamin D3, Plaquenil, Gabapentin, Provigil , Advair, Nasonex, and Proventi