Author Topic: Overview of Immunobiologics for Salivary Gland Disease  (Read 266 times)

markt

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Overview of Immunobiologics for Salivary Gland Disease
« on: August 14, 2019, 11:08:23 AM »
Good overview of Immunobiologics for Salivary Gland Disease:

https://onlinelibrary.wiley.com/doi/pdf/10.1111/odi.13062

To the articles credit, I have done better with oral symptoms while on Rituximab (Anti CD-20 Mab). 

More interestingly, the article has been updated for Iscalimab (the new Anti CD-40 Mab being developed by Novartis that has the communities interest for many reasons).

For those interested in the trial:  https://www.hopkinssjogrens.org/research/cfz533/

Interestingly, this study is evaluating two distinct Sjogrens patient populations:  High and Low systemic disease groups.  It is refreshing to see studies now being opened to consider including many of us that do not fit squarely into the box known as the AECG Sjogrens diagnosing criteria.

Mark

Sharon

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Re: Overview of Immunobiologics for Salivary Gland Disease
« Reply #1 on: August 14, 2019, 03:34:31 PM »
Thanks for the info Mark.
I'll also add for the record that Abatacept has helped resolve some serious salivary gland issues I was having.
If anybody finds a similar article like this one on lacrimal gland disease (SS dry eye) I would be grateful!
 
Sjogren's (+ RA?) positive ANA, RNP, RNP-A, APCA salivary gland swelling, dry mouth & eyes,, eyelid swelling & redness, photosensitivity, fatigue, severe joint pain, multiple sensitivities and allergic reactions 
Orencia, Restasis, Paleo Diet, Vit. D & C, Ubiquinol 200mg, Omega 3...

irish

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Re: Overview of Immunobiologics for Salivary Gland Disease
« Reply #2 on: August 23, 2019, 09:11:35 PM »
That had a lot of good info in it. About time they started getting more sjogrens oriented...I swear Sjogrens has just about every autoimmune symptom in the book. Getting some good help for the eyes would be great. Thanks. irish