Author Topic: increased BAFF found in most sjogren patients  (Read 348 times)

happylife

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increased BAFF found in most sjogren patients
« on: July 07, 2018, 11:42:46 PM »
Hello

Found this interesting research paper. It says increased levels of BAFF is found in most sjogren patients.

This could help in diagnosis and also help researchers in new drug Discovery.

https://www.technologynetworks.com/drug-discovery/articles/antibodies-in-drug-discovery-identifying-novel-biomarkers-to-overcome-sjgrens-syndrome-290837

cccourt1942

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Re: increased BAFF found in most sjogren patients
« Reply #1 on: July 08, 2018, 09:15:56 AM »
Thx.  This is intriguing.  In addition, it is the closest to any possibility for cure or control...or even a possible decline in the advancement the disease.  When I say that, I mean within a generation--or less.  IF this is accurate.  The problem...as always...is accurate studies---actually, following enough subjects over a long enough time.  This disease (known by our oral histories alone) is one which waxes and wanes.  Takes a long time to overcome one of us.  Finding that many people at the same level of intensity of the disease is the challenge.  (not to mention how do they tell??)….thx for the info/post.  VERY interesting/promising.
ccc
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markt

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Re: increased BAFF found in most sjogren patients
« Reply #2 on: July 08, 2018, 03:39:07 PM »
https://acrabstracts.org/abstract/safety-and-efficacy-of-single-dose-vay736-anti-baff-r-mab-in-patients-with-primary-sjogrens-syndrome-pss/

Novartis has our number; this biologic addresses just that.  Coincidentally, it is being trialed where I live in Jacksonville. 


happylife

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Re: increased BAFF found in most sjogren patients
« Reply #3 on: July 09, 2018, 08:00:24 AM »
Thanks Markt

This is dated September 2016, almost 2 years ago. Results seems to be promising, so has this drug been approved beyond the trials?

markt

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Re: increased BAFF found in most sjogren patients
« Reply #4 on: July 09, 2018, 03:43:12 PM »
Its in Phase-2 trials through fall 2019.  It may be available now on a case by case basis via FDA Expanded Access.

happylife

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Re: increased BAFF found in most sjogren patients
« Reply #5 on: July 09, 2018, 07:10:47 PM »
Do you know anyone one who has taken this drug?

If yes what are the improvements they found.

Did you ask your rhumetologist about this drug? What did he say?

SjoGirl

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Re: increased BAFF found in most sjogren patients
« Reply #6 on: July 10, 2018, 04:36:08 PM »
Thanks for sharing. I wonder what, if any, progress was made on this over the past year?
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