Author Topic: First gene therapy study in human salivary gland shows promise...  (Read 2924 times)

olmphoto2

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Monday, November 5, 2012

Excerpt:

"Gene  therapy can be performed safely in the human salivary gland, according to  scientists at the National Institute of Dental and Craniofacial Research  (NIDCR), part of the National Institutes of Health.

This  finding comes from the first-ever safety, or Phase I, clinical study of gene  therapy in a human salivary gland.  Its results, published this week in  the Proceedings of the National Academy of Sciences, also show that the  transferred gene, Aquaporin-1, has great potential to help head and neck cancer  survivors who battle with chronic dry mouth. Aquaporin-1 encodes a  protein that naturally forms pore-like water channels in the membranes of cells  to help move fluid, such as occurs when salivary gland cells secrete saliva  into the mouth.

These  initial results clear the way for additional gene therapy studies in the  salivary glands. Although sometimes overlooked, salivary glands present  an ideal target for gene therapy. They are easily accessible and, once a  gene is introduced, it has no obvious escape route into the bloodstream, where  it can have unintended consequences..."



http://www.nih.gov/news/health/nov2012/nidcr-05.htm

The  National Institute of Dental and Craniofacial Research is the Nation's leading  funder of research on oral, dental, and craniofacial health.
Mary Ann in Wisconsin

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Aquarius

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Re: First gene therapy study in human salivary gland shows promise...
« Reply #1 on: December 16, 2012, 03:43:53 PM »
This is exciting news.  I am cautiously optimistic that impressive gene therapy advances will be made in the next 5 years.