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Sjogrens Topics => Living With Sjogren's => Topic started by: Confused on June 28, 2019, 01:46:37 PM

Title: Nuvigil
Post by: Confused on June 28, 2019, 01:46:37 PM
Does nuvigil interact with other meds in an adverse way?
Is nuvigil a good to med to counter falling asleep while in a conversation?
Title: Re: Nuvigil
Post by: SoCalGord on June 28, 2019, 02:31:28 PM
Nuvigil does have a few precautions about potential drug interactions in its labeling.

It is listed as an inducer of CYP3A4 - this is the enzyme that is responsible for the metabolism of many drugs.  What this means is that concentrations of drugs metabolized by this enzyme could be lower than they would normally be, and this could potentially mean that they would not be effective anymore. They specifically comment on oral contraceptives and cyclosporin as examples.

Nuvigil is also listed as an inhibitor of CYP2C19.  This enzyme metabolizes drugs such phenytoin, diazepam and others. This means that concentrations of these drugs could be higher if they are taken together and this could result in more adverse effects.

Please talk through the pros/cons/risks with your doctor and/or pharmacist. (