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Sjogrens Topics => Living With Sjogren's => Topic started by: yankeeinthesouth on April 03, 2010, 08:09:52 AM

Title: Question on Plaquenil Dosage ?????
Post by: yankeeinthesouth on April 03, 2010, 08:09:52 AM
Can anyone tell me what dosage strength of Plaquenil they are on.  My Dr put me on 200 mg a day, but I have heard that low of a dose will not help much. This is all so confusing because it seems that every Dr has a different opinion.....

Thanks for everyones help.
Title: Re: Question on Plaquenil Dosage ?????
Post by: harrigan on April 03, 2010, 08:16:50 AM
It is worked out for your body weight, so perhaps that is why it is a lower dose?  Or maybe the DR wants to see how you tolerate a lower dose 1st?
Title: Re: Question on Plaquenil Dosage ?????
Post by: DragonflyC on April 03, 2010, 08:52:51 AM
Hmm. . .I only weigh about 115 lbs., and I'm on 400 mg a day (200 mg taken twice a day).
Title: Re: Question on Plaquenil Dosage ?????
Post by: lynnmarie219 on April 03, 2010, 10:55:03 AM
I also take 200 mg two times a day but I'm a far cry from being underweight!  ;)

I agree that maybe the doc wanted to see how you tolerate the med first and then slowly move you up to a higher dosage if needed.

Have you asked him/her about why that dosage was prescribed for you? It might be the place to start...there could be a very good reason for it that has to do with you and your other medications or medical history.  Just a thought.....
Title: Re: Question on Plaquenil Dosage ?????
Post by: anita on April 03, 2010, 10:59:12 AM
400 mg for me too.

It can cause stomach upset in some people, so I guess he wants to see how you tolerate it.  I would ask him what his plan is...how long at 200 mg, then when (if) he plans to raise it.

Title: Re: Question on Plaquenil Dosage ?????
Post by: BonusMom on April 03, 2010, 11:22:04 AM
600 mg daily for me.
Title: Re: Question on Plaquenil Dosage ?????
Post by: Scottietottie on April 03, 2010, 01:22:43 PM
Hi - I was started on 200mg per day but didn't feel it had 'done' anything so 4 months later my rheumy increased the dose to 400mg daily. A couple of months after that I thought I could feel a difference.

Take care - scottie  :)
Title: Re: Question on Plaquenil Dosage ?????
Post by: Nancy60 on April 03, 2010, 01:33:48 PM
I was started on 200mg/day for 2-3 weeks to see how I tolerated it, then increased to 400 mg/day (split between AM and PM).  we tried to reduce to 200 mg awhile back but I flared with that so I am staying at the 400 mg dose now.

Nancy
Title: Re: Question on Plaquenil Dosage ?????
Post by: jstroble on April 03, 2010, 02:26:55 PM
I was on 400 mgs. too.  When the side effects got bad, it was reduced to 200 mgs.  Didn't seem to make much of a difference.

Joyce
Title: Re: Question on Plaquenil Dosage ?????
Post by: lindaneall on April 03, 2010, 02:44:04 PM

In '08 I was on 400mg. of brand name Plaquenil for 8 months. I am 5'10" and 120 lbs. Things started out fine, but after about 5 months I developed sharp GI pains that would leave me doubled over. In fact, we wondered if I had also had developed Celiac and had an upper endoscopy done. Negative.  At 8 months I also developed tinnitus. Unfortunately, the Plaq. didn't seem to help my severe fatigue issues at all.  My rheumy had me stop. Thankfully my bad side effects immediately went away  (except some mild lingering tinnitus).

My IGG levels (along with other Sjs markers) continue to be very high, along with low WBC.  Ten days ago my rheumy wanted me to go back on it and see if I can even tolerate 200mg. a day.  He said, "Even though it didn't help the fatigue issues before, Plaquenil can help to stop the progression of Sjs. Even a little is better than nothing."  Unfortunately, this time I am starting out with symptoms.  A very unsettled stomach, and it is hard to eat much.  I do take it with food.  So, if my symptoms don't improve soon, I think I'm going to stop. I'll try to hang out a little longer. Somehow I think my body just is extremely sensitive to this med.

Linda
Title: Re: Question on Plaquenil Dosage ?????
Post by: Lesleybird on April 05, 2010, 12:17:22 AM
   The dose should be 300mg. to 400mg. a day for an average size person. Most doctors use 400mg. I think. Ask your pharmacist and he or she wound know what dose is most commonly ordered by doctors. Some people with decreased kidney or liver function may need a lower dose.    Lesley
Title: Re: Question on Plaquenil Dosage ?????
Post by: gurs on April 05, 2010, 04:33:48 AM
My rheumy said that 400mg day was the absolute max....for anyone??

You may not feel much better on plaquenil, but it will halt the progression.
Title: Re: Question on Plaquenil Dosage ?????
Post by: Patze on April 05, 2010, 04:50:53 AM
I'm on 400 a day as well...


Patze
Title: Re: Question on Plaquenil Dosage ?????
Post by: yankeeinthesouth on April 05, 2010, 08:41:44 AM
Thanks everyone. I appreciate your input.

I asked my rheummy if he would be going up on the dose and he said no. I asked why and he said just because he didn't want to increase the dose......no explanation.

I have heard that every dr is different and they have their own way of treating patients. So I just hope that my rheummy really knows his stuff.

I have an appt in May with another rheummy and I would like to know what she says.

Title: Re: Question on Plaquenil Dosage ?????
Post by: eyeamdry on April 05, 2010, 11:29:19 AM
Me too, 400 mg day.
Title: Re: Question on Plaquenil Dosage ?????
Post by: roetta on April 05, 2010, 12:40:41 PM
I'm on 400 a day also. I'm 5'1" and 100lbs. It's a high dosage for my weight but my rheummy was reluctant to lower the dosage because my SED rates have been high the last two visits.

Title: Re: Question on Plaquenil Dosage ?????
Post by: yankeeinthesouth on April 05, 2010, 03:40:58 PM
How many people notice a difference or feel better on the higher dose?
Title: Re: Question on Plaquenil Dosage ?????
Post by: Prairie Gal on April 05, 2010, 03:47:58 PM
I'm usually on 400 mg/day (200 in a.m. and 200 in p.m.).   On two occasions my rheumy has told me to cut one of the tablets in half, for a total of 300 mg/day.   After 3-4 weeks I feel worse, so I e-mail him and ask if I can go back to the 400 mg/day.  I do feel better  on 400 mg -- I wish I could say I feel "terrific!"  I'm 5'8" and weigh 142 lbs.

Prairie gal
Title: Re: Question on Plaquenil Dosage ?????
Post by: meow on April 06, 2010, 10:03:22 AM
Unfortunately, this time I am starting out with symptoms.  A very unsettled stomach, and it is hard to eat much.  I do take it with food.

Linda, I have read that taking plaquenil at the sameyou take vitamins (even with food) makes the GI effects worse. Some people take their vitamins at lunch to avoid this. Maybe that would help?
I have been taking it  for 3 weeks and I'm not liking it at all. Ringing in the ears almost immediately, itchy little bumps all over my back,  and headaches. I know that the side effects are usually faster to appear than the benefits, but I don't know if I can hold out for 3 months to see if it helps. So this week I cut it to 200 mg once a day, to see if the side effects go away, and they have improved. I haven't called the rheumy yet, even though the rx info said to if you get the ringing in the ears. I guess I should call her!

Title: Re: Question on Plaquenil Dosage ?????
Post by: yankeeinthesouth on April 06, 2010, 04:57:18 PM
Thanks everyone for the replys.

I am still new to this so I really appreciate everyones input. I am just wondering why my rheummy said only 200 mg per day, when it seems that most people benefit from the higher dose.

It gives me one more question for the dr when I go back to him at the end of the month.

Thanks.